Peptides in skincare.
Peptides are short chains of amino acids — the building blocks of proteins. In topical skincare, peptides are designed to send specific signals to skin cells, mimicking the natural signalling that triggers collagen production, elastin synthesis, or muscle relaxation. Categories include signal peptides (Argireline), carrier peptides (copper peptides, GHK-Cu), enzyme-inhibitor peptides, and matrikines (matrixyl).
What it does
Different peptides drive different effects. Argireline (acetyl hexapeptide-8) at 10% concentration relaxes expression-line muscles, mimicking botulinum toxin's mechanism at the topical level. Copper peptides support collagen synthesis and wound healing. Matrixyl drives matrix repair and reduces fine lines. The category as a whole is the gentler alternative to retinoids — slower visible change, far fewer tolerance issues.
The evidence
Solid for individual peptide molecules. Argireline 10% has the strongest peer-reviewed support for visible expression-line softening. GHK-Cu has decades of research supporting collagen and wound-healing effects. The peptide category as a whole has less developed clinical evidence than retinol, but the leading molecules are credible.
Who should use it
Anyone seeking gentler anti-ageing actives — particularly users with sensitive skin, pregnancy/breastfeeding (when retinoids are contraindicated), post-procedure recovery, or anyone uncomfortable with the retinol introduction period. Compatible with most other actives.
What it pairs with
Retinol (different mechanism, complementary effect — use peptides AM, retinol PM). Niacinamide (synergistic for barrier support). Vitamin C (combine in AM routine for antioxidant + signal-peptide effect). Hyaluronic acid (hydration foundation).
What to buy in Australia
The Ordinary Argireline Solution 10% — AU$13, the affordable benchmark for signal peptides. The Ordinary Multi-Peptide + Copper Peptides 1% Serum — AU$28, copper peptides at consumer pricing. Drunk Elephant Peptide Eye Gel — AU$110, the premium peptide eye treatment.
Frequently asked questions.
- Are peptides as effective as retinol?
- On expression-line softening (the wrinkles caused by repeated facial movement), Argireline-class peptides at 10% concentration come close to retinol's effect. On overall texture, tone, and pore appearance, retinol consistently outperforms. Honest summary: peptides do less, more gently.
- How long until I see results from peptides?
- 8–12 weeks of consistent twice-daily application. Slower than retinol. Anyone selling faster is overpromising.
- Are peptides safe in pregnancy?
- Generally yes (always confirm with your doctor). Peptides are widely considered pregnancy-safe and are the standard anti-ageing recommendation for pregnant users when retinoids are contraindicated.
- Can I use multiple peptide products in one routine?
- Yes. Different peptide types target different mechanisms and combining them is standard in advanced anti-ageing routines.