What Is Tretinoin? — The Strongest Retinoid
Tretinoin is prescription-strength retinoic acid. It's the most-evidence-supported anti-aging molecule available.
The science.
Tretinoin is the active form of vitamin A. While retinol must convert to retinoic acid in the skin (a 2-step process that loses potency), tretinoin is the active form directly.
How it works
Tretinoin binds directly to retinoic acid receptors, instructing cells to behave more like younger cells. Increased turnover, more collagen, more even pigmentation. The most potent over-the-counter equivalent is 0.5-1% retinol.
Right for which skin types?
Ages 25+ with active acne or visible aging. Requires prescription in Australia.
How to use it
0.025-0.05% to start. Pea-sized to dry skin, twice weekly. Build to nightly over 12 weeks. SPF non-negotiable.
Side effects
More irritation than retinol. Initial peeling and redness ('retinisation') is significant. Pause during pregnancy.
Top recommendations.
- Tretinoin 0.025% Cream by Rx in AU — $45 · Entry strength
- Tretinoin 0.05% Cream by Rx in AU — $50 · Standard strength
- Tretinoin 0.1% Cream by Rx in AU — $60 · Maximum strength
Common questions.
How do I get tretinoin in Australia?
GP or dermatologist prescription. Online clinics (e.g. Skin Renu, Honeydew) prescribe via consultation.
Tretinoin vs retinol — when to upgrade?
If retinol at 0.5-1% has worked for 6+ months and you want stronger results.
Is tretinoin safer or harder than retinol?
Same molecule end-state. Tretinoin is more aggressive but predictable. Retinol is gentler but slower.